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Fig. 11. Simulation of the development of the homozygous EphA3 knockin map in
mouse colliculus compared to normal. The 100 retinal cells were assigned
equiprobably to one of two categories, distinguished by the colours green
(EphA3+) and black (EphA3-). The initial pattern of
connectivity was random, and initially there were weak gradients of ephrinA
and ephrinB over the colliculus. The maps shown are the projections from
retina onto colliculus with the projections from the EphA3+ and the
EphA3- cells shown separately. (A) Control. EphA densities
in EphA3+ cells and the EphA3- cells are determined as
for the wild-type case used in Fig. 2. A highly organised map (bottom left
panel) develops from an initially disorganised state (middle left panel).
(B) Homozygous EphA3 knockin (##/++). The EphA densities as shown in
Fig. 2A were used. From the initially disorganised map, two separate ordered
maps are formed (bottom row), with the green EphA3+ map more
rostral than the black EphA3- map. The red rectangle in the top
left hand figure of A,B encloses the set of retinal cells that were used to
make the one-dimensional connectivity plots shown in Fig. 4G-L.
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