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Figure 10


Fig. 10. `Transdifferentiation' of ZII-negative to ZII-positive PCs. Transverse 40 µm cryostat sections of the paramedian lobule (PM) from the adult Ebf2 null mouse cerebellum were double immunofluorescence stained, as labeled. (A-C) Low-definition images of the paramedian lobule (PM) of the hemisphere reveal a high number of transdifferentiated ZII-positive/beta-gal-positive PCs. Higher magnification images (D-F) confirm colocalization (arrows) of beta-gal and ZII expression in the null mutant PM lobule. (G) Conversely, at the same paramedian level in the heterozygous cerebellum, the distributions of ZII (brown, arrows) and lacZ (blue, arrowheads) are strictly non-overlapping and mutually exclusive. Scale bars: in C, 150 µm for A-C; in F, 50 µm for D-F; in G, 100 µm.





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