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Figure 4


Fig. 4. Cerebellar anlage abnormalities in mouse embryos with ectopic expression of Lmx1a. (A-F). Dorsal view of E12.5 whole embryos (A,B) and their dissected neural tubes (C-F). Arrows indicate dramatically expanded medial single cell layer in transgenics (B,D,F). (G-W) Paramedial sagittal sections of E12.5 cerebella with genotypes and markers indicated, together with quantification of each cell type. In all panels, insets show a higher magnification of the boxed regions. Roof plate (arrow in H showing Gdf7 and arrows in J showing Lmx1a+/Msx1/2+ cells) was expanded to the ventricular surface within the anlage. Arrowheads in I and J point to Lmx1a-/Msx1/2+ cells located adjacent to Lmx1a+/Msx1/2+ roof plate cells. (K,N,Q,T,W) Quantification of number of c1, RLS, pc2 and c2-c4 cells in Lmx1a transgenic embryos. * indicates P<0.01. Bars indicate s.e.m.





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