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Fig. 5. Melanocyte development in Sox10Sox8ki/Sox8ki mice.
(A) Comparison of 7-day old Sox10Sox8ki/Sox8ki mice (top)
and wild-type littermates (bottom). Sox10Sox8ki/Sox8ki mice are
white and smaller than wild type. (B) Skin preparations from 7-day-old
wild-type mice and Sox10Sox8ki/Sox8ki littermates shown from the
side and from below to visualize hair and hair follicle. (C)
Whole-mount in situ hybridization was performed on wild-type and
Sox10Sox8ki/Sox8ki embryos at 12.5 dpc using antisense riboprobes
against Dct, Kit and Mitf. The regions from which pictures were taken are
boxed in the embryo in the lower left corner.