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Fig. 1. Genomic structure of the dizzy locus and embryonic dizzy expression. (A) The dizzy locus comprises eight exons (UTRs dark gray). The P-elements of dizzy^EP and of dizzy^P are inserted into exon 0 at positions +39 and +46, respectively. The various alleles dizzyⁿ have been obtained by imprecise excision of dizzy^EP and delete the transcription start site or the translation start site. The inset shows neighboring genes of dizzy. (B) All conserved domains of the PDZ-GEF Dizzy are encoded by exon 3: cNMP, cyclic nucleotide binding domain; RasGEFN, N-terminal Ras-GEF domain; PDZ, PDZ domain; RA, Ras association domain; RasGEF, Ras-GEF domain. The deletions of the alleles dizzy³ and dizzy¹⁰ predict the expression of truncated Dizzy proteins lacking the cNMP domain (gray triangles: predicted translation starts); dizzy¹² might lead to the expression of a protein without cNMP, RasGEFN and PDZ domains. (C) dizzy RNA is ubiquitously expressed during embryogenesis at relatively low levels. (D) Embryos homozygous or hemizygous for one of the alleles associated with a deletion of the transcription start site (here dizzy⁸ homozygous) show no expression: the signal is indistinguishable from a signal obtained by the sense probe (not shown).

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