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Figure 7


Fig. 7. Dizzy behaves like a Rap1-GEF in vivo. Embryos solely expressing dominant-negative rap1N17 (A,C) compared with embryos simultaneously expressing rap1N17 and dizzyEP (B,D) in macrophages. (A) The expression of rap1N17 severely disrupts the migration of macrophages along the VNC. (B) This effect of rap1N17 is rescued by the simultaneous expression of dizzy, presumably by substituting for GEFs sequestered by Rap1N17. (C,D) Similarly, the effect of Rap1N17 on macrophages migrating along the dorsal edge (C) is rescued by the coexpression of dizzy (D). A,B: sagittal optical sections; C,D: magnifications of similar areas as indicated by the rectangle in Fig. 6C.





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