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Figure 8


Fig. 8. Dizzy- and Rap1-induced cell adhesion require integrin function. Dizzy (A) and Rap1V12 (E) can induce similarly strong cell shape changes in macrophages. (B,F) These changes depend on the function of ßPS integrins, as both Dizzy (B) and RapV12 (F) fail to show the effect in a mys mutant background. (C,D) Macrophages at the dorsal edge of a wild-type (C) and a mys mutant (D) embryo. The latter (lacking only the zygotic mys contribution) is indistinguishable from wild type concerning macrophage shape and motility. Embryos at stage 14; field of view as in Fig. 6D-K.





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