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Figure 2


Fig. 2. Ventral cell types are lost in FGFR double mutants. RNA in situ hybridization analysis of E12.5 coronal brain sections using radioactive probes. (A,E,I) In the control embryo, expression of Pax6 (A), Dlx2 (E) and Nkx2.1 (I) are used to identify the dorsal, ventral and ventromedial areas of the telencephalon. (B,F,J) In the Fgfr2-/-;Fgfr3-/- mutant, dorsoventral patterning and morphology of the telencephalon are grossly normal. (C,G,K) In the Fgfr1-/-;Fgfr3-/- mutant, although the borders of expression of Pax6 (C), Dlx2 (G) and Nkx2.1 (K) are normal (arrowheads), indicating proper dorsoventral specification of precursor cells, the morphology of the ventral telencephalon is abnormal and flattened in appearance. (D,H,L)In the Fgfr1-/-;Fgfr2-/- mutant, ventral precursor cells are lost, indicated by expression of Pax6 that extends to the ventral midline (D) and by the loss of Dlx2 (H) and Nkx2.1 (L) expression.





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