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Figure 5


Fig. 5. The Fgfr1-/-;Fgfr3-/- SVZ is expanded and undergoes more cell death and less cell cycle exit. (A-C) RNA in situ hybridization of E12.5 coronal sections through the ventromedial area. Unlike the control, Prox1 expression in the mutant expands from the SVZ to the ventricular surface (A). This expansion coincides with an apparent decrease in the expression of the VZ markers Hes5 and Lhx2 (B,C). Scale bar: 0.02 mm. (D) Control and mutant E11.5 brains doubled-labelled for Ki67 and BrdU (injected 24 hrs prior to sacrifice). (E) A larger percentage of Ki67+BrdU labelled cells over total BrdU-labelled cells is present in the mutant compared with the control, indicating an abnormally low rate of cell cycle exit. TUNEL analysis (F) indicates a higher rate of cell death in the mutant at E11.5.





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