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Figure 10


Fig. 10. Abilities of the Tg39, Tg55 or Tg50 transgenes to rescue the LR defects of Pitx2{Delta}ASE/{Delta}ASE mice. Phenotypes of Pitx2{Delta}ASE/{Delta}ASE neonates expressing the transgenes of lines Tg39 (A,D,G), Tg55 (B,E,H) or Tg50 (C,F,I) are shown. The transgene of line Tg39 rescued the great artery defect (A), whereas that of line Tg55 rescued the abnormal rotation of the gut (H) apparent in Pitx2{Delta}ASE/{Delta}ASE mice. The transgene of line Tg50 was unable to rescue any of the defects examined (C,F,I). Right isomerism of the lungs was not rescued by any of the transgenes (D-F); the number of lobes is indicated in yellow. Blue arrows in G-I indicate the location of the duodenum. Encircled + or - signs indicate whether LR defects were rescued or not, respectively. ao, aorta (blue asterisk); pa, pulmonary artery (yellow asterisk); pc, pancreas.





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