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Fig. 4. Wnt9a and Wnt4 act redundantly in maintaining joint
integrity. (A) Van Kossa/Alcian Blue/Eosin-stained sections through
the ankle (a,d), knee (b,e) and foot region (c,f,g) of wild-type
(=Wnt9a+/-; Wnt4+/-) and
Wnt9a-/-;Wnt4-/- newborn littermates. (a) Ankle
joint. (b) Knee joint. (c) Foot region. (d,e) Synovial chondroid metaplasia in
the ankle joint (d, arrow) and in the joint capsule of the knee (e, arrow) of
Wnt9a-/-;Wnt4-/- mutants. (f) Fusion between
the intermediate cuneiform and navicular tarsal elements (arrow). (g) Fusion
between the calcaneus and cuboid tarsal elements (arrow) and synovial
chondroid metaplasia in the joint capsule ligament of digit I (asterisk).
(B) Sections through the wrist regions of newborns, E13.5 and E15.5
embryos. (a,e) Van Kossa/Alcian Blue/Eosin staining, showing normal
arrangement of carpal elements in wild type (a) and fusion of the three carpal
elements 2, c and 3 in Wnt9a-/-;Wnt4-/- mutants
(e). (b,f) Gdf5 staining on wrist sections. The three carpal elements
2, c and 3 are separated in wild type (b) and
Wnt9a-/-;Wnt4-/- mutants at E13.5 (f). (c,g)
Gdf5 staining on wrist sections. The three carpal elements are
separated in wild type (d) but are fused in the
Wnt9a-/-;Wnt4-/- mutants (g). (d,h)
Col2a1 staining. The carpal elements in wild type (d) but are fused
in Wnt9a-/-;Wnt4-/- mutants (h).
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