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Fig. 5. Temporal regulation of Ihh expression by Wnt9a signaling.
In situ hybridization on serial sections showing the humerus region of
wild-type and Wnt9a-/- littermates. (A-D) Ihh
expression at E11.5, E12.5, E13.5 and E14.5 in wild-type and
Wnt9a-/-; showing no significant difference at E11.5 (A),
downregulation of Ihh expression at E12.5 (B) and E13.5 (C), and
delayed separation of the Ihh expression domains at E14.5 (D) in
Wnt9a-/- humeri. (E) Size reduction of the
Ppr expression domain in Wnt9a-/- humeri compared
with wild type at E13.5. (F) Increased Col10a1 expression
domain at E12.5 in Wnt9a-/- humeri. (G) Strongly
reduced Col10a1 expression domain at E13.5 and E14.5 (H) in
Wnt9a-/- humeri. Reduced expression levels of
Ptch1 in chondrocytes and perichondrium (I), of Pthrp
in the articular region (shoulder joint) (J), and of Runx2
(K) and Osx (L) in the perichondrium/periosteum.
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