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First published online July 27, 2006

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Cyclin to the terminal

Several cyclins are responsible for regulating the cell cycle, but their regulatory plasticity makes their distinct roles difficult to define. On p. 3201, Jacobs and colleagues discuss the particularly puzzling case of Cyclin A, which is essential for Drosophila embryonic viability but is needed only for certain types of mitoses. In the embryonic ectoderm, Cyclin A is only required for the very last division before cells become post-mitotic. The researchers have found that this is because during normal mitotic cycles, Cyclin A and Cyclin E function redundantly to prevent the premature activity of Fizzy-related/Cdh1 (Fzr), which targets the B-type Cyclins and String/Cdc25 for degradation. By contrast, before terminal mitoses, Cyclin E is inactivated early, leaving Cyclin A to work alone - this means that in Cyclin A mutants untimely Fzr activation prevents completion of the division programme. Observations from other labs, and those made in this paper, indicate that Cyclin A is also crucial for terminal mitoses in neuroblast lineages.

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Terminal mitoses require negative regulation of Fzr/Cdh1 by Cyclin A, preventing premature degradation of mitotic cyclins and String/Cdc25

Achim Reber, Christian F. Lehner, and Henning W. Jacobs
Development 2006 133: 3201-3211. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?