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Figure 1


Fig. 1. Range of Hh activation in the wing disc. (A, part a) A schematic of Drosophila wing imaginal disc staining [adapted from Callejo et al. (Callejo et al, 2006)]. Anterior (A) is to the left. (a,b) Hh-producing cells in the posterior (P) compartment are shown in green. Ptc (red) appears as a stripe that abuts the AP boundary. (A, part c) Expression of relevant target genes. Engrailed (En, blue) and Patched (Ptc, pink) are high threshold targets. Decapentaplegic (Dpp, yellow) and Collier (not shown) are medium threshold targets, and Iroquois (Iro, orange) is a low threshold target. (A, part d) A graphic representation of target activation represented by the colours above, as a function of local Hh concentration. The vertical line represents the AP compartment boundary. (B) Cross-section of a wing imaginal disc. The wing pouch is covered by an epithelium called the peripodial membrane (PM). The lumen between the disc proper cells and the PM is the peripodial space (PS). Here, the PM is highlighted with horse radish peroxidase (HRP) (micrograph courtesy of Laurence Dubois, Centre de Biologie du Développement, Toulouse, France).





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