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Fig. 10. AVE defects in Nap1^khlo mutants. (A-D) Cells of the AVE, marked by expression of Cerl at E6.5 (A,B) and Hex at E7.5 (C,D), were present at the embryonic-extraembryonic boundary of wild-type embryos (A,C), but failed to migrate completely in half of the Nap1^khlo mutants examined (B,D, brackets). Anterior is to the left. (E-H) All Hex-GFP-expressing cells migrated towards the anterior of wild-type embryos at E6.0 (E,G), but some Hex-GFP cells remained distal (F, arrow) or migrated to the posterior (H, arrows) in half of the Nap1^khlo embryos examined (green, Hex-GFP; red, phalloidin). Anterior is out in E and F, and to the left in G and H. (I,J) High magnification anterior views of the Hex-GFP-expressing cells in E6.0 wild-type (I) and Nap1^khlo (J) embryos. Vertical arrows in I and J represent the orientation of the proximodistal axis. Note that that although the wild-type AVE cells are elongated along the proximodistal axis, the Nap1^khlo cells are not. Scale bars in E-J: 50 µm.

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