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Figure 2


Fig. 2. Histological analysis of E8.5 Nap1khlo mutants. (A,B) The primitive streak region of wild-type embryos contained a small number of mesenchymal cells (A, arrowhead), whereas the Nap1khlo primitive streak contained a mass of disorganized mesenchymal cells (B, arrowhead). (C,D) The layered organization of myocardium (black arrows) and endocardium (white arrows) in the wild-type heart (C) was present in Nap1khlo mutant hearts (D). The foregut (asterisk) formed a closed pocket in wild-type embryos (C), but failed to close in Nap1khlo mutants (D).





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