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Figure 8


Fig. 8. Behavior of nascent mesoderm and endoderm. (A-D) Cripto (A,B) and Lim1 (C,D) expression in nascent mesoderm cells; these markers occupied their normal domains in Nap1khlo mutants (B,D) compared to wild-type embryos (A,C) at E7.5. (E,F) By E7.5, Cerl-expressing cells of the foregut migrated to the anterior of wild-type embryos (E), but failed to reach the anterior of Nap1khlo mutant embryos (bracket, F), and instead accumulated adjacent to the primitive streak (arrowhead). (G,H) Foxa2 expression in wild-type (G) and Nap1khlo mutant embryos (H) at E7.5. The Foxa2-expressing foregut domain failed to reach the anterior of Nap1khlo embryos (bracket). Anterior is to the left in all panels.





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