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Figure 7


Fig. 7. Cyclin A and Cyclin E suppress Fizzy-related/Cdh1 lacking all Cdk consensus phosphorylation sites. (A-L) The prd-Gal4 transgene was used to drive various UAS transgenes in alternating segments. Embryos after the stage of mitosis 16 were immunolabeled with anti-tubulin (Tub) and a DNA stain (DNA) for a comparison of the cell densities in segments with (middle segment) and without UAS transgene expression (outer segments). The UAS transgenes were UAS-fzr (C,D), UAS-fzr and UAS-CycA (E,F), UAS-fzrpsm (G,H), UAS-fzrpsm and UAS-CycA (I,J) and UAS-fzrpsm and UAS-CycE (K,L). The UAS-fzrpsm transgene results in expression of a Fzr version in which all of the Cdk consensus phosphorylation sites (S/T P) are eliminated. A control embryo without an UAS transgene is shown in A,B. UAS-fzr and UAS-fzrpsm expression inhibits mitosis 16 and therefore results in a twofold lower cell density. Co-expression of either UAS-CycA or UAS-CycE suppresses this inhibition of mitosis 16.





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