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Figure 3


Fig. 3. Osx1-GFP::Cre removal of ß-catenin function affects skeletal development. Skeletal preparations of ß-cateninc/n (wild type) and Osx1-GFP::Cre;ß-cateninc/n (mutant) embryos at E14.5, E16.5 and E18.5. Higher magnifications of the fore- and hindlimbs are presented below each embryo. White arrowheads indicate comparable levels of hypertrophy between wild-type and mutant tibia. Arrows indicate the absence of mineralized bone matrix in mutants when compared with wild-type embryos (black arrowheads).





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