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Fig. 9. Proposed model for the role of Hh and canonical Wnt signaling in
regulating the differentiation of skeletal progenitors. Various lines of
evidence implicate the importance of canonical Wnt signaling at multiple
stages along the osteoblast differentiation pathway, from the specification of
early skeletal progenitor cells to a terminally differentiated osteoblast.
Observations from these studies (Hu et
al., 2005; Day et al.,
2005), together with results presented in this study, have been
used to synthesize a working model for the specific functions of Hh and
canonical Wnt signaling during osteoblast specification and differentiation.
See text for details. Red and green arrows indicate the requirement for Hh and
canonical Wnt signaling, respectively; the blue line represents the negative
regulation of osteoclasts by OPG.
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