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Fig. 1. Basement membrane disruption and radial glial endfeet detachment in
laminin 
1III4-/-, perlecan-/- and
6-integrin-/- cortex at midneurogenesis. Fluorescent
micrographs of immunostained (as indicated in the panels) frontal sections of
telencephali of embryonic day (E) 14 wild-type and mutant littermates.
(A-D) Laminin immunoreactivity underneath the pial surface (arrowheads
in A) and surrounding the blood vessels (arrows in A). Insets (a-d) depict
representative high-power views of the BM in the respective mouse line.
Arrowheads in C,D indicate disruptions of the BM. (E-J) The absence of
BLBP-immunoreactive radial glia endfeet (arrowhead in E,G) in the laminin
1III4-/- (F,H), perlecan-/- cortex (I) and
6 integrin-/- cortex (CTX; J) compared with wild type (E,G).
Ectopic BLBP-positive cell somata in the laminin 1III4-/-
cortical plate (CP) (arrows in F,H). The broken white line (E) indicates the
ventricular surface (VS). CTX, cerebral cortex; GE, ganglionic eminence; VZ,
ventricular zones. Scale bars: 200 µm in A-D; 50 µm in E,F; 25 µm in
G,H; 100 µm in I,J.
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