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Figure 3


Fig. 3. FGF3 and FGF8 act downstream of Squint and Bozozok. Sqt (D,J), Boz (E,K) and ß-catenin (C,I) can induce expression of fgf3 (B-E) and fgf8 (H-K). fgf3 and fgf8 are expressed in the future dorsal region in wild-type (A,G) but not in uninjected ichabod (B,H) embryos. Boz induces fgf3 and fgf8 through Sqt (E,F,K,L). In ichabod embryos, Boz can induce weak expression of fgf3 (E) and fgf8 (K), but this expression is abolished in the presence of MOsqt (F,L). (M-T) Nodal proteins, but not Boz, are required for ß-catenin induction of fgf3 and fgf8. The induction of fgf3 and fgf8 observed in ichabod embryos injected with ß-catenin RNA (compare M with N and Q with R) is abolished in the presence of MOs against sqt and cyc (O,S) but not by pNAboz (P,T). Embryos are shown at sphere stage.





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