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First published online August 14, 2006

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Repressive PUFs on developmental signalling

The spatial and temporal regulation of gene expression during development occurs at the level of both gene transcription and gene translation. Now, Walser and colleagues reveal that three members of the PUF family of translational repressors that regulate certain aspects of germline development in C. elegans also negatively regulate vulval development in this organism (see p. 3461). PUF proteins - socalled because the first to be identified were the Drosophila Pumilio and the C. elegans FBF proteins - bind to their target mRNAs through PUF repeat motifs. Using detailed genetic analyses, the researchers show that fbf-1 and fbf-2 act redundantly to inhibit the specification of the primary vulval cell fate, which is induced by MAPK signalling. puf-8, they report, plays a distinct role in vulval development by temporally restricting the response of vulval precursor cells to this and other patterning signals. Because PUF proteins are highly conserved, the researchers suggest that these translational repressors may fine-tune other signalling pathways during animal development.

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Related articles in Development:

Distinct roles of the Pumilio and FBF translational repressors during C. elegans vulval development

Claudia B. Walser, Gopal Battu, Erika Fröhli Hoier, and Alex Hajnal
Development 2006 133: 3461-3471. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?