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First published online August 14, 2006

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TWEAKing mammary gland apoptosis

Unlike most organs, mammary glands undergo massive changes during adult life. Epithelial cells proliferate extensively during pregnancy to generate milk for the offspring. When lactation stops, these cells apoptose and the gland is remodelled to its resting state (involution). Baxter and co-workers have been investigating the regulation of involution and, on p. 3485, they report that this process can be halted by the conditional deletion of the gene encoding IKK2 (inhibitor of B kinase). This is one of the kinases that regulate the nuclear factor-B (NF-B) pathway, which controls many cellular responses, including apoptosis. The researchers report that the delayed mammary gland apoptosis and remodelling they see in the conditional mutant is associated with decreased expression of the death receptor ligand TWEAK, which contains binding sites for both NF-B and FOXO (forkhead transcription factors) in its promoter region. These new insights into the control of apoptosis in a physiological situation may provide new therapeutic approaches to the treatment of breast cancer, suggest the researchers.

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Related articles in Development:

IKKß/2 induces TWEAK and apoptosis in mammary epithelial cells

Fiona O. Baxter, Paul J. Came, Kathrine Abell, Blandine Kedjouar, Marion Huth, Klaus Rajewsky, Manolis Pasparakis, and Christine J. Watson
Development 2006 133: 3485-3494. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?