|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 7. Model for signaling input into cadherin function in cell motility.
DE-cadherin appears to receive positive input from PCP and RTK (e.g. Egfr)
signaling, which it translates into directed cell movement. The Egfr input
could be either direct (as suggested from cell biology literature) or via
nuclear signaling input, as suggested by the observed interaction with the
ETS-factor Pointed. DN-cadherin serves as a `brake' to this movement, and
might directly affect DE-cadherin expression. See text for details.
|
