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Fig. 3. Cell body maintenance defects in sax-8 mutants. (A)
Maintenance defect of amphid chemosensory neurons in sax-8 mutants.
Arrows indicate the nerve ring, and arrowhead indicates cell bodies of
chemosensory neurons that are anteriorly misplaced. Scale bar: 7 µm. L1 and
L4, freshly hatched first and fourth larval stage animals, respectively; A,
3-day-old adult. Error bars indicate standard error of proportion. (B)
Quantification of chemosensory neuron displacement. (L1: n=22-85; L4:
n=21-53; A: n=93-172). (C,D) Defect in the
cell body position of the PVQ neurons. PVQL and PVQR are two bilateral neurons
normally placed posterior to the anus. The PVQ cell body can often be found
severely misplaced in sax-8 mutants. Notably, the axon still reaches
the posterior region and projects normally in all cases. The axon and cell
body defects are independent of one another in all alleles, as it is extremely
rare that both defects are seen in the same animal (data not shown). E, L1 and
A, are early threefold embryos, freshly hatched L1 larvae and young adults,
respectively. Error bars indicate the standard error of proportion. (C)
Displacement of the PVQ cell body in sax-8 mutants. Arrows indicate
the normal position; arrowhead indicates the anteriorly displaced cell body.
Scale bars: 5 µm. (D) Quantification of PVQ cell body displacement. (E:
n=138-180; L1: n=38-158; A: n=190-438.)
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