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Fig. 6. Positional cloning of sax-8. (A) Summary of
sax-8 genetic map data. Based on the observed recombination
frequencies (as shown), we calculated the position of sax-8 to be at
-0.95±0.45. (B) Gene structure of sax-8/dig-1/K07E12.1,
taken from
www.wormbase.org.
The sax-8/dig-1 defects can be rescued with cosmids K07E12 and R05H11
(see Table 1) and with cosmid
K07E12 alone (data not shown). (C) Domain structure of DIG-1 and mutant
alleles.