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Figure 6


Fig. 6. Zfp488 induces ectopic oligodendrocyte precursor markers in the presence of Notch signaling activation. Chick neural tubes at the stage HH14 (E2.5) stage were electroporated with expression vectors for Zfp488 (A,B), NICD (C,D) or both constructs (E-H), and harvested 3 days later at E5.5. Sections of chick neural tube were hybridized with the probes as indicated. Transgene (Tg) was detected by Zfp488 (A,E) and NICD (C). Overexpression of neither Zfp488 (A,B) nor NICD (C,D) alone could induce ectopic oligodendrocyte marker expression. The combination of NICD and Zfp488 induces expression of ectopic oligodendroglial markers Sox10 (F, arrow) and Pdgfra (G, arrow), but not Mbp (H).





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