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Figure 4


Fig. 4. The postmigratory germ cell marker GCNA1 is precociously expressed in premigratory germ cells in Dnmt1-deficient embryos.

Embryos were immunostained for SSEA1 with TG-1 (red) and for GCNA1 (black). (A) TG-1 and GCNA1 immunohistochemistry of a 12.5 dpc embryo, demonstrating that both markers specifically recognize germ cells. The inset shows that GCNA1 reactivity at this time is normally restricted to the TG-1-positive population. Arrow and arrowhead indicate GCNA1-expressing and non-expressing germ cells, respectively. (B) 8.5 dpc Dnmt1c/c yolk sac with a TG-1 and GCNA1-expressing cell. The inset shows a higher magnification view of the doubly stained cell. (C) Numerous TG-1- and GCNA1-positive cells in a 9.5 dpc Dnmt1c/c embryo.





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