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Fig. 3. Localization of phospho-MAPK1/MAPK3 and phospho-MAP2K1/MAP2K2 in
wild-type and Map2k1-/- placentas.
Anti-phospho-MAPK1/MAPK3 and anti-phospho-MAP2K1/MAP2K2 staining of E9.5
(A) and E10.5 (B) wild-type, Map2k1-/- and
Map2k2-/- placentas. (A) At E9.5, MAP2K1/MAP2K2 were
phosphorylated in cells lining the maternal sinuses (black arrows), in cells
of the allantois (red arrowheads), and in some labyrinthine trophoblasts of
wild-type, Map2k1-/- and Map2k2-/-
placentas. However, phospho-MAPK1/MAPK3 signal was primarily found around
maternal sinuses (black arrows) and in some labyrinthine trophoblasts in
wild-type and Map2k2-/- specimens. In
Map2k1-/- placentas, MAPK1/MAPK3 were activated only in
the allantois (red arrowhead). (B) At E10.5, phospho-MAP2K1/MAP2K2 signal was
also observed in the vascular endothelial cells lining the embryonic blood
vessels (black arrowheads). Despite the high activation of MAP2K2 at the
chorioallantoic interface (red arrows) and in the allantois of
Map2k1-/- placentas (red arrowhead), phospho-MAPK1/MAPK3
were detected only in the allantois (red arrowhead). al, allantois; ev,
embryonic blood vessel; l, labyrinth; ma, maternal sinus. Scale bar: 50
µm.
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