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Figure 8


Fig. 8. Models. (A) Possible function of UNC-51 and UNC-14 in the regulation of UNC-5 localization. UNC-51 and UNC-14 may affect the formation, selection or transport of the vesicles and their associated UNC-5. (B) An UNC-5 silencing model. The gray ovals represent Netin/UNC-6. The green `Y's represent UNC-5. UNC-5 may be packaged in small vesicles to inhibit its surface expression in DD/VD neurons. Some unknown `UNC-5 surfacing signal' may relocate UNC-5 to the cell membrane where the growth cones respond to Netrin/UNC-6, resulting in dorsal extension. In this model, we show that UNC-5 is localized at the cell surface after the `UNC-5 surfacing signal'; however, we did not observe the surface localization of UNC-5::GFP by using a fluorescent microscope at the L4 stage. We think that part of UNC-5::GFP localizes at the cell surface, and that this is enough for the function. Alternatively, the surface localization may be temporary.





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