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First published online August 25, 2006

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A Snail trail to Wg-induced death

The periphery of the fly eye is a good place to study the final stage of positional signalling. Here, Wingless (Wg) signalling induces concentrically arranged cellular specializations, such as the pigment rim, which shields the eye from extraneous light. The pigment cells that form this structure originally surrounded the peripheral ommatidia of the eye, which die during pupal eye development. On p. 3529, Lim and Tomlinson report that three Snail family transcription factors - Worniu, Snail and Escargot - and the enzyme Notum are Wg signalling targets at the edge of the fly eye. Notum limits the extent of Wg signalling, but Snail gene expression, they report, is required for removing the peripheral ommatidia and for forming the peripheral rim. Because Snail family proteins are expressed only in a subset of ommatidia cells, not in the photoreceptors that die, Lim and Tomlinson propose that a death signal released from the Snail-family-expressing cells directs the death of the photoreceptors.

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Related articles in Development:

Organization of the peripheral fly eye: the roles of Snail family transcription factors in peripheral retinal apoptosis

Hui-Ying Lim and Andrew Tomlinson
Development 2006 133: 3529-3537. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?