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First published online August 25, 2006

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Mammary development: no Hedgehog required

Hedgehog (Hh) signalling is essential for the development of many vertebrate epidermal appendages, including hair and teeth. Another epidermal appendage that shares a common origin is the mammary gland. But, as Hatsell and Cowin now report, positive Hh signalling is absent throughout the embryonic and postnatal development of mouse mammary glands (see p. 3661). In mammals, three Gli transcription factors act downstream of Hh: the activator Gli2 induces the expression of Gli1, which antagonizes the repressor activity of Gli3. The researchers show that although Gli2 and Gli3 are expressed during embryonic mammary development, Hh target genes are not expressed. Furthermore, whereas mammary gland development is normal in mice that lack Gli1 or Gli2, two pairs of mammary buds are missing in Gli3^xt/xt mouse embryos, which do not make Gli3. Misactivation of the Hh pathway by targeted expression of Gli1 in Gli3^xt/+ mice also induces mammary bud loss. Thus, the researchers conclude, Gli3-mediated repression of Hh signalling is required for normal embryonic mammary development.

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Related articles in Development:

Gli3-mediated repression of Hedgehog targets is required for normal mammary development

Sarah J. Hatsell and Pamela Cowin
Development 2006 133: 3661-3670. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?