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Fig. 3. AHNPs maintain viability and assume glial phenotypes upon ventricular
transplantation. (A) AHNPs cells injected into the right lateral
ventricle of postnatal day 3 mice were detectable with HNA in periventricular
tissue adjacent to injection site (*). (B) HNA+
cells (boxed in a) were primarily located within 100 µm of the ventricular
wall in the ependymal and subependymal cell layer. (C-E)
HNA+ cells (red) integrating into the LV wall display conserved
morphology of astrotypic cells, and frequently co-express GFAP (green).
(F) Confocal micrograph shows GFAP+ process extension from
an AHNP into the subependymal zone. (G,H) Activated dendrimer
transfection of Pax6-eGFP of 30 PDs AHNPs 3 days post-transfection. (I)
Lentiviral-eGFP transfection of 30 PD AHNPs (20 moi). Scale bars: 40 µm in
B; 25 µm in C-E; 8 µm in F; 20 µm in G-I. Images in C-F,H are
counterstained with DAPI.
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