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Fig. 7. Expression of cell cycle regulators and apoptosis in
ß-catenin and Ptch1 mutant embryos. Results of
immunohistochemistry with the indicated antibodies on limb sections of the
indicated genotypes is shown. (A) Expression of the indicated cell
cycle regulators in the distal humerus at 14.5 dpc. Boxed areas representing
negative (left) and positive (right) staining regions in the wild-type sample
and corresponding regions in every mutant are shown at higher magnification as
insets in the lower left and right corners, respectively. (B)
Expression of p21 and detection of cell death by fluorescent TUNEL assays on
tibia sections at 18.5 dpc. Apoptotic cells are stained green; nuclei are
stained blue by DAPI. p21 expression and apoptosis were greatly increased in
the Catnbc/-; Col2a1-Cre mutant.
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