spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 1


Fig. 1. Dominant-negative frizzled receptor mutants inhibit Myf5 expression. (A) Quantitative analysis of Myf5 activation in explants. PSM and the first somites (I-IV) of Myf5nlacZ/+ targeted mice (Tajbakhsh et al., 1996) were co-cultured for 3 days with neural tube and C3H10T1/2 cells expressing Frizzled1{Delta}N (Fz1{Delta}N), Frizzled6{Delta}N (Fz6{Delta}N), Frizzled7{Delta}N (Fz7{Delta}N) or Sfrp3, or with control cells (C). Independent experiments (n=6) were performed in triplicate and averaged. (B) Schematic representation of the frizzled receptor structure compared with the frizzled {Delta}N mutants used in this assay and Sfrp molecules. CRD, cystein-rich domain; NLD, netrin-like domain; red bands, transmembrane domains.





Right arrow Return to article