spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 8


Fig. 8. Summary of MES-mediated histone methylation and models for the roles of the MES proteins in silencing the X chromosome in the germ line. (Left) The MES-2/MES-3/MES-6 complex catalyzes di- and trimethylation of H3K27, and preferentially concentrates H3K27me3 on the X chromosome (Bender et al., 2004). We hypothesize that MES-2/MES-3/MES-6 function repels MES-4 from the X chromosome and from regions of the autosomes (Fong et al., 2002) (this study). (Right) Two models for the role of MES-4. (Top right) MES-4 dimethylation of H3K36 in or near an autosomal gene (dotted line) activates that gene to express a repressor (labeled `R') of many X-linked genes. (Lower right) MES-4 concentrates H3K36me2 on the autosomes; MES-4 or H3K36me2, in turn, repels a repressor (labeled `R') from the autosomes, focusing its binding or action on the X chromosome. We speculate that the silencing of genes on the X chromosome is achieved by the combined repressive effects of H3K27me3 and repressor `R' action.





Right arrow Return to article