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Figure 8


Fig. 8. Man1 is required for cell survival and normal nuclear morphology. Immunostaining on serial paraffin-embedded sections from wild-type and mutant embryos at the 17-somite stage with antibodies to phospho-histone H3 (PH3; A,B), activated caspase 3 (aCas3; C,D) and single-strand DNA (ssDNA; E,F). (G,H) Hematoxylin-Eosin staining as a reference. ot, otic vesicle; ba, first branchial arch; op, optic vesicle; fb, forebrain vesicle. (I-O) Transmission electron microscopy of wild-type (I,K) and Man1{Delta}/{Delta} (J,L-O) embryos at E9.5. (I,J) The mesenchyme in the branchial region. (K-O) The nuclear shapes of wild-type and Man1{Delta}/{Delta} mesenchymal cells. The insets in M and N show herniated nuclei. Arrow in O indicates an expanded perinuclear space. Scale bars: 100 µm in A-H; 10 µm in I,J; 1.0 µm in K-O.





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