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Fig. 3. Ccnd1-/- cerebella show a postnatal size defect.
The midline cross-sections of wild-type littermates (A-C) are shown
next to Ccnd1-/- (cycD1 on figure) pups
(D-F). At P0 there is no difference in cerebellar size (A,D), but by P6
Ccnd1-/- cerebella are markedly smaller (B,E). The
relative size difference is maintained but not increased by P12 (C,F).
(G) Quantification of the relative cerebellar midline area. (H)
Total body weight of Ccnd1-/- pups continued to fall
further behind wild-type littermates from P6 to P12. (I) The size of
the granule cell population was similarly decreased at P6 and P12. Scale bars:
500 µm. The number of littermates analyzed at each time point is indicated
in each chart.
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