(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.
Fig. 2. Genetic mapping and molecular cloning of cogc-3(k181) and
cogc-1(k179) mutants. (A) (Top) Genetic map of
cogc-3 and cogc-1 loci. (Middle) The exon and intron
structures of cogc-3 and cogc-1 genes. Arrowheads indicate
the positions of transposon insertions. (Bottom) The PCR fragments used for
injection rescue experiments. (B) Homology between COGC-3 and Homo
sapiens (Hs) Sec34 (COG-3). (C) Homology between COGC-1 and Hs
ldlBp (COG-1). Black boxes indicate identical amino acids. (D) Domain
structures of COGC-3 and COGC-1. Conserved domains are shown in colored boxes
with percentages of amino acid identity in human and C. elegans
homologs. Amino acid positions in C. elegans proteins are shown in
parentheses. The gene products of cogc-3 and cogc-1
correspond to the GenBank entries AB212858 and AB212859, respectively.
