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Fig. 3. RNA interference of components of the COG complex. Schematic
diagrams of the COG complex in mammals (A) and C. elegans
(B). Nomarski images of the posterior gonad arms of animals treated
with RNAi directed against cogc-1 (C), cogc-2
(D), cogc-3 (E) or cogc-4 (F). Anterior
is leftwards. Dorsal is towards the top. Scale bar: 25 µm. The migration
paths of DTCs are depicted by orange lines and arrowheads. (G)
Percentages of anterior and posterior gonad arms with DTC migration defects in
RNAi knockdowns of COG components in the wild-type background. n=30
for each experiment. The following cDNAs were used for RNAi analysis of COG
complex components: yk31b12 corresponds to cogc-1; yk324g6 to
C06G3.10/cogc-2; yk863b10 to cogc-3; yk402e5 to
Y51H7C.6/cogc-4; yk621c10 to C43E11.1/cogc-5; yk29e8 to
K07C11.9/cogc-6; yk730h8 to W01B6.9/cogc-7; and yk26e9 to
R02D3.2/cogc-8. The error bars represent the mean±s.d. The
values were calculated from the data collected from the first and second half
of the animals examined.
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