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Fig. 1. p53 in a neural stem cell niche. (A-C,E-G) Nuclear p53-immunoreactivity is seen in the majority of cells in lateral wall of the lateral ventricle (LV) and to a lesser degree in the rostral migratory stream (RMS), whereas levels are lower or undetectable in most cells in the surrounding areas of the adult mouse brain. (D,H) Three-dimensional reconstructions of confocal stacks demonstrate p53 in musashi 1 (Msi1) and Gfap-immunoreactive cells. Nuclei are labeled with DAPI and appear blue. The orientation of all sections is indicated in A. D, dorsal; M, medial. Scale bars: 10 µm.





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