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Fig. 2. Increased proliferation in a neural stem cell niche in the absence of
p53. More cells incorporate BrdU (A-C) and display
immunoreactivity to the M-phase specific epitope phospho-histone H3
(D-F) in the lateral ventricle wall (LVW) of
p53-/- mice compared with wild-type littermates. The
number of TUNEL labeled apoptotic cells was not significantly different
between wild type and p53-/- mice. Numbers represent LVW
positive nuclei per brain section. Positive nuclei were counted on serial
coronal sections of the anterior horn of the lateral ventricle within a
defined space of the subventricular zone. (H) Quantification of the
proportion of LVW cells capable of forming primary neurospheres.
*P<0.05, **P<0.01. Scale bars:
10 µm.
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