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Fig. 1. Morphology of the forebrain of wild-type, Fez^-/-Fezl^+/-, Fez^+/-Fezl^-/-, Fez^-/-Fezl^-/- and Fez^+/-Fezl^+/- mice. Coronal (A-D,I-L) and sagittal (E-H) sections of E15.5 (A-H), E17.5 (I-L) wild-type (A,E,I), Fez^-/-Fezl^+/- (B,F,J), Fez^+/-Fezl^-/- (C,G,K), and Fez^-/-Fezl^-/- (D,H,L) mice. (M-Q) Sagittal sections of E18.5 Fez^+/-Fezl^+/- (M-O) and Fez^-/-Fezl^-/- (P,Q) mice at the level where posterior commissures (M,P, indicated by white arrowheads), habenulo-interpeduncular tracts (N,Q, white arrows) or mammillthalamic tracts (O, black arrowhead) were observed. Nissl staining. Fez^-/-Fezl^+/- mice had a very small olfactory bulb and Fez^+/-Fezl^-/- showed a reduction of the dentate gyrus (arrow in K,L), compared with wild-type littermates. Fez^-/-Fezl^-/- mice showed loss of the olfactory bulb (arrow in H), dentate gyrus and the CA3 region of hippocampus (arrow in L), prethalamus, strong reduction of the thalamus (region between arrowheads) and a reduced neocortex. At E18.5, both Fez^+/-Fezl^+/- and Fez^-/-Fezl^-/- mice had a posterior commissure and habenulo-interpeduncular tract. The habenulo-interpeduncular tracts were small and abnormally located, due to severe reduction of the thalamus in Fez^-/-Fezl^-/- mice. Fez^+/-Fezl^+/- (O), but not Fez^-/-Fezl^-/- mice, had mammilothalamic tracts. DG, dentate gyrus; hit, habenulo-interpeduncular tract; hip, hippocampus; ht, hypothalamus; ma, mamillary region; mtt, mammilothalamic trancts; ncx, neocortex; OB, olfactory bulb; pc, posterior commissure; th, thalamus; pt, pretectum; pth, prethalamus; s, septum; 3v, third ventricle. Scale bars: 0.5 mm.

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