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Fig. 9. Schematic presentation of a role of Fez and Fezl in
diencephalon patterning. Fez and Fezl are expressed in
the telencephalon and rostral diencephalon (prospective prethalamus) and
function to suppress the formation of the caudal diencephalon, which expresses
Irx1 and Wnt3a. In the absence of Fez and
Fezl, the rostral diencephalon does not form and instead caudal
diencephalon expands rostrally at E9.5. Subsequently at E10.5, the prethalmaus
and the ZLI, which is normally located in the interface between the
prethalamus and thalamus, do not form in
Fez-/-Fezl-/- embryos. The caudal
diencephalon, including the thalamus and pretectum, is expanded in
Fez-/-Fezl-/- embryos. The formation
of thalamus, however, is dependent on inductive signals (e.g. Shh) from the
ZLI. In Fez-/-Fezl-/- embryos, the
thalamus does not grow properly, but the anterior pretectum remains expanded
at E12.5. apt, anterior pretectum; di, diencephalon; pth, prethalamus, ppt,
posterior pretectum; tel, telencephalon; th, thalamus.
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