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Fig. 1. The development of dbh-positive cervical sympathetic ganglia
(CSG) is severely affected in hands off embryos. Whole-mount in
situ hybridization for dbh in wild-type (A,B) and
hands off mutant embryos (C,D) at 2 dpf (A,C) and 3 dpf
(B,D). dbh-positive CSG cells (arrowheads) are missing in hands
off embryos, whereas dbh-positive cells in the dorsally located
medulla oblongata are not affected [asterisks; noradrenergic neurons of the
medulla oblongata/area postrema form a semicircle
(Holzschuh et al., 2003),
giving the impression of two stripes in the oblique view from lateral
shown].