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Figure 6


Fig. 6. Tolloid cannot functionally replace Tlr1. (A-F) Confocal images of the innervation patterns of ventral internal muscles in intact third instar larvae stained with CD8-GFP-Sh. Arrows indicate the locations of NMJs on muscles 12, 13, 6 and 7. (A) In a tlr1D427/tlr1K788 mutant animal, NMJs are mislocalized on muscle 12 and reduced to a remnant in the cleft of muscles 6 and 7. (B) All terminals are at their correct location and structured normally in a tolloid (tld10E95/tld9B66) mutant larva. (C) The neuromuscular innervation pattern appears wild-type in kuzbanian (kuze29/kuzK01403) mutants. (D) Overexpression of Tlr1 in all neurons using Elav-Gal4 rescues the tlr1 mutant phenotype. (E) Overexpression of Tld with Elav-Gal4 does not rescue the NMJ pattern in tlr1 mutants. NMJs on muscles 12 and 13 are mislocalized in this hemisegment. (F) Overexpression of Kuzbanian in all neurons does not restore the innervation defects in tlr1 mutants. NMJs are mislocalized on muscles 12 and almost absent on muscles 13, 6 and 7. Asterisks indicate NMJs located on muscles that are outside of the intended focal plane.





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