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Figure 8


Fig. 8. Cadherin regulates synaptic contacts. (A-C) Morphology of horizontal cells expressing cN390{Delta}. Projection images and optical vertical sections are shown in upper and lower panels, respectively. The dendrite terminals of type I/III and type II horizontal cells correctly target the PNAL-positive and PNAL-negative sublamina, respectively. (D-K) Higher magnification views of single optical sections at the level of double-cone pedicles. The dendrite terminals expressing full-length N-cadherin (D-G) and the cN390{Delta} (H-K) are shown in green and the synaptic markers PNAL (D,H,F,J) and GluR4 (E,G,I,K) in magenta. Many of the dendrite terminals of type I (H) and type III (J) horizontal cells covered smaller areas of the double-cone and accessory-cone pedicles, respectively (arrows). GluR4 expression is either absent (arrows) or suppressed (arrowheads) in the regions that have received projections from horizontal cells expressing the cN390{Delta}, shown as a broken line (I,K). Scale bars: 10 µm A-C; 5 µm D-K.





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