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Fig. 3. Identification of novel GI-restricted TFs. (A) Schematic
representation of relative expression levels, in light (lowest expression) to
dark (highest) purple, of 161 sample transcripts out of 1240 that are enriched
in the small and large intestine; colon was analyzed twice in the study from
which the data are extracted (Zhang et
al., 2004). The most common extra-intestinal sites of expression
were stomach, liver and pancreas; most mRNAs are expressed sparingly in other
tissues. (B) Intersection of these gene expression data (34 TFs) with
the GIfT survey, revealing developmental representation of 23 TFs that are
highly enriched in GI expression. (C) Detailed expression profile of
these 23 TF genes in 55 adult and embryonic mouse tissues; again, data are
taken from Zhang et al. (Zhang et al.,
2004). In each row, the TF gene is listed towards the left, every
square represents an organ and expression levels are represented by a color
scale (red-orange, high; yellow-green, low; white, absent). Expression levels
in adult small intestine and colon are marked with `I' and `C', respectively.
Predominant phenotypes reported in knockout mice are indicated on the right.
(D) Northern analysis of adult mouse tissues, showing significant
intestine enrichment (and possibly exclusive expression) of the novel TF
transcript corresponding to Gene ID 71597 (last row in panel C), for which we
propose the name Isx.
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