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Fig. 4. Regulatory pathways that influence germline cell death. (A)
The pathways that influence C. elegans germline cell apoptosis.
Proteins discussed in the text are included. A physiological germ cell death
is mediated through the ras pathway, with MPK-1 (MAP kinase) representing the
most downstream component. Genotoxic treatments such as radiation induce
checkpoint genes and p53-mediated apoptosis. Both pathways act to regulate a
core pathway required for all normal cell deaths in C. elegans.
EGL-38 and PAX-2 are drawn to act in parallel to the other two pathways, but
could alternatively act downstream of MPK-1 (or CEP-1). (B) Genetic
epistasis experiments between C. elegans Pax2/5/8 genes and other
genes that affect germline apoptosis, carried out in an otherwise wild-type
genetic background. (C) Genetic epistasis experiments between C.
elegans Pax2/5/8 genes and other genes that affect germline apoptosis,
carried out in animals RNAi-depleted for ced-10, a gene required for
corpse engulfment. Germ-cell corpses were quantified as described in Materials
and methods. Data are mean number of cell corpses per gonad arm±s.e.m.
Wild type is N2.
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